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hip pain after covid vaccine pfizer

It will take only 2 minutes to fill in. People aged under 30 will be offered a different vaccine in the UK (Picture: Metro.co.uk) People who have had the Oxford AstraZeneca coronavirus vaccine . and transmitted securely. Search NHS Inform - Click here to submit this form, Show Long-term effects of COVID-19 Navigation. COVID-19 vaccines can cause mild side effects after the first or second dose, including: Pain, redness or swelling where the shot was given Fever Fatigue Headache Muscle pain Chills Joint pain Nausea and vomiting Swollen lymph nodes Feeling unwell Most side effects go away in a few days. Gently exercising the arm also increases blood flow to the area which can provide additional relief. 03-14-2021 08:37 PM. Case presentation: Scottish Government - Opens in new browser window, Last updated: Reactive arthritis in patients attending an urban sexually transmitted diseases clinic. Bethesda, MD 20894, Web Policies ReA after COVID-19 vaccination is rare. J Med Virol. If your symptoms get worse or you're worried, call 111. Maryam Masoumi. Finally, she was diagnosed as ReA after CoronaVac vaccination and was administered a single intra-articular injection of 1 ml compound betamethasone. Yes, you can take OTC pain meds after getting the Covid vaccine, says CDC plus other tips for dealing with side effects. The report added that the reactions to the vaccines could be moderate in intensity, but resolved within a few days after vaccination. California Privacy Statement, Ideggyogy Sz. Remember, in any given week you'd expect a certain number of people to develop health complications, regardless of whether they are vaccinated or not. Google Scholar. Careers. J Clin Epidemiol. The very common side effects are the same and should still only last a day or two. Google Scholar. People aged 16 and over, and some children aged 12 to 15, can also get a booster dose. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Reports of serious side effects are very rare. RMD Open. 2008;59(1):113121. Cite this article. 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Calabrese LH, Naides SJ. Wed like to set additional cookies to understand how you use GOV.UK, remember your settings and improve government services. @AKgirl2 - If the pain persists, you should probably have it checked out by a doctor. COVID-19 Vaccine-Related Arthritis: A Descriptive Study of Case Reports on a Rare Complication. Manage cookies/Do not sell my data we use in the preference centre. The authors of this study said that this raises the possibility that NSAIDs might also affect the immune response to coronavirus vaccination. SARS-COV-2 usually presents with respiratory symptoms but can have various other manifestations and sequelae. You cannot catch COVID-19 from the vaccine but it is possible to have caught COVID-19 and not realise you have the symptoms until after your vaccination appointment. Epub 2022 Jul 22. Patient should abduct shoulder by 60 degrees and place hand on the ipsilateral hip (Figure 1). doi: 10.7759/cureus.26702. https://doi.org/10.1097/00000441-200608000-00008. It is over a month after your second dose, so this is not a short term effect or potential problem, related or not to the shot. She consequently presented to the clinic ten days after her discharge, complaining of walking difficulties and radiating pain in her right hip. 2021 Feb;21(2):181-192. doi: 10.1016/S1473-3099(20)30843-4. Itchy Throat: Could It Be COVID-19 or Something Else? "Vaccination is the single most effective way to reduce deaths and severe illness from COVID-19," said the MHRA. And of course, rest. Prof Peter Openshaw, of Imperial College London, agreed the study showed a small increased risk after vaccination. Little data on pain relievers and COVID-19 vaccine, Dont take a pain reliever before your COVID-19 vaccine, Centers for Disease Control and Prevention (CDC). Wiley; 2016. p. 124365. Covid vaccines and rare clots - what do we know? A summary of her laboratory results and her vital information is available in Table1. | National Library of Medicine Disclaimer. Finally, she was diagnosed as ReA after CoronaVac vaccination and was administered a single intra-articular injection of 1 ml compound betamethasone. Google Scholar. However, ultrasound images of the soft tissues around the hip revealed an increase in the thickness of synovium and articular effusion in the hips neck with a 7mm diameter (Fig. Zhang C, Wu Z, Li JW, Zhao H, Wang GQ. Its possible to develop shingles after COVID-19 vaccination or after having COVID-19, but cases are rare. Article Ultrasonic images of soft tissue around the hip. The patient was started on 100mg indomethacin twice a day and 80mg IM depot prednisolone based on this diagnosis. 2022 Jul 9;14(7):e26702. You get any of these symptoms starting from around 4 days to 4 weeks after being vaccinated: There have been rare cases of inflammation of the heart (myocarditis) reported after COVID-19 vaccination. Cennimo said the pre-COVID-19 vaccine research in children found that taking a fever-reducing drug only affected the production of antibodies if the drug was taken before the injection. Before READ MORE:Pfizer vaccine: Four 'troubling' side effects that mainly follow second dose of Covid jab, "Pfizer-BioNTech COVID-19 Vaccine is still being studied in clinical trials.". PubMed A 58-year-old Iranian woman with a previous history of hypertension, coronary heart disease, and type 2 diabetes was admitted to the emergency room complaining of unproductive cough, shortness of breath, and extreme fatigue. Dr. David J. Cennimo, an infectious disease physician and assistant professor at Rutgers New Jersey Medical School, said these are signs of an appropriate recognition and immune reaction to the vaccine.. Rich E, Hook EW, Alarcn GS, Moreland LW. But catching coronavirus is more risky for your health which is why doctors recommend people get immunised. 2021 May 29;21(1):499. doi: 10.1186/s12879-021-06211-7. It lasted one day. PubMed You have accepted additional cookies. 2020;55(5):105954. doi: 10.1016/j.ijantimicag.2020.105954. 2008;59(1):11321. Probiotic supplements can be used as one part of an immune-boosting protocol to help reduce the likelihood of coronavirus infection. Tehran University of Medical Sciences, Tehran, Iran, Student Research Committee, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, Clinical Research and Development Center, Shahid Beheshti Hospital, Qom University of Medical Sciences, Beheshti Blvd, Qom, Iran, Tahereh Eftekhari,Rasoul Shajari&Maryam Masoumi, You can also search for this author in With less inflammation, he said, there may also be a lower immune response to the vaccine. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Find out about the side effects and safety of the COVID-19 vaccine for children. A few days ago, the lower back and hip pain started up again. The swelling and pain nearly disappeared after 2 d. On 1month follow-up, her condition was normal. Her initial symptoms were suggestive of polymyalgia rheumatica, and she had nearly complete response to steroids. View our Twitter - (This will open in a new window). Learn how it feels and how to manage it. The Oxford jab tended to have more mild side effects if you were 65 or older in age. I have heard of someone having sudden back pain the day after the second shot of Moderna's product, but it resolved by the next day. Previous studies have reported ReA following HIV infection as well as with dengue and chikungunya viruses [10,11,12]. The patient reported no family history of psoriasis, inflammatory bowel disease or autoimmune reactions and had not traveled to any new location in the past 6months. 2005-2023 Healthline Media a Red Ventures Company. I never had back/hip pain. The estimated "R" number the reproduction rate has remained between 0.6 to 0.9 across the UK, suggesting the size of the pandemic is shrinking. The coronavirus vaccine helps protect you from getting COVID-19. sharing sensitive information, make sure youre on a federal Dont include personal information e.g. More info. In the study, following the first dose of vaccine, there were: Meanwhile for people who had a coronavirus infection, there were approximately: There was also an increased risk of bleeds on the brain in the first seven days after a positive Covid test, but risks returned to a normal, baseline level within a month. J Am Acad Physician Assist. The coronavirus vaccine helps protect you from getting COVID-19. You have rejected additional cookies. Wiley; 2016. p. 124365. Pain and stiffness worse after not moving (for example, when you wake up) Hot, swollen hip and a high temperature or feeling hot and shivery. Reactive arthritis is a form of spondyloarthritis that typically manifests with the involvement of one or a few joints asymmetrically following an infection episode, classically with genitourinary or gastrointestinal microorganisms [8, 9]. Can Nigeria's election result be overturned? There were 10 frequently reported reactions to the jab, happening to more than one in 10 people, which included: Again, these reactions ranged from mild to moderate but passed within a few days following the injection. An uncommon side effect is swollen glands in the armpit or neck on the same side as the arm where you had the vaccine. This downward trend has also been seen in the number of patients admitted to hospital, so let's hope it stays that way. Can a COVID-19 Vaccine Increase Your Risk of Shingles. The approved COVID-19 vaccines have also been tested on millions of people in the UK and around the world, including: All vaccines used in the UK must be approved by the independent Medicines and Healthcare products Regulatory Agency (MHRA). Chat to an NHS operator in our Live Chat - opens a new window, your pain is affecting your day to day life, you're worried about possible long COVID symptomsin a child or young person under 18. Fatty liver disease symptoms: Nail changes could signal the condition, Covid vaccine side effects: After effects 'more common' second time, Diabetes type 2 symptoms: Foot drop is a sign of high blood sugar, Coronavirus vaccine: The most common side effects of the jab exposed. 2020;35(5):15451549. Do we miss rare adverse events induced by COVID-19 vaccination. RMD Open. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). This information is a copy of the product information for COVID-19 vaccines and medicines, which outlines the conditions under which the products should be used and information on its known safety. One of the rare complications of COVID-19 infection is Reactive Arthritis. Side effects of the coronavirus vaccines developed by Pfizer and Moderna are common, and they become more frequent after the second dose. Efficacy and risk of mRNA vaccination in patients with autoimmune inflammatory rheumatic diseases. Next review due: 24 April 2023, side effects and safety of the COVID-19 vaccine for children, Moderna (Spikevax) COVID-19 vaccine patient leaflet on GOV.UK, Oxford/AstraZeneca COVID-19 vaccine patient leaflet on GOV.UK, Pfizer/BioNTech COVID-19 vaccine patient leaflet on GOV.UK, a severe headache that is not relieved with painkillers or is getting worse, a headache that feels worse when you lie down or bend over, a headache that's unusual for you along with blurred vision, feeling or being sick, problems speaking, weakness, drowsiness or seizures (fits), a rash that looks like small bruises or bleeding under the skin, shortness of breath, chest pain, leg swelling or persistent abdominal (tummy) pain, a fast-beating, fluttering or pounding heart (palpitations), children and young people aged between 12 and 17. We use some essential cookies to make this website work. This site needs JavaScript to work properly. More research is needed, of course. Stay at home and get a test. It is important to note that the Covid vaccines can still engender a number of side effects, from mild to serious, although the benefits of getting vaccinated far outweigh the risks posed by the virus. They say it remains unclear why these links appear and suggest more studies are needed to understand this. | Smolen JS, Aletaha D, IB MI. Reverse Transcription Polymerase Chain Reaction, Mean Corpuscular Hemoglobin Concentration, Serum Glutamic-Oxaloacetic Transaminase (Aspartate aminotransferase), Serum Glutamic-Pyruvic Transaminase (Alanine transaminase). Dr. Sherrill Brown, medical director of infection prevention at AltaMed Health Services, a federally qualified healthcare center serving Los Angeles and Orange counties in California, agrees. Recurrent Acute Pancreatitis in a Patient with COVID-19 Infection. MM, KS, and SM planned and carried out the laboratory tests. Find out more about what to expect after your COVID-19 vaccination on GOV.UK, Report a vaccine side effect on the COVID-19 Yellow Card website. 2004;18(5 SPEC. https://doi.org/10.1002/art.1780390715. Kishimoto M, Lee MJ, Mor A, Abeles AM, Solomon G, Pillinger MH. A person may experience some side effects of the COVID-19 vaccine, including pain at the injection site, fatigue, headache, and, in rare cases, an arthritis flare. Lopez-Gonzales reported 4 cases of acute arthritis during COVID-19 admission, all of which had rheumatologic background diseases [13]. For most people, the side effects of the vaccine are mild or moderate and last only a day or two. If you are due for a mammogram in the few weeks after the vaccine, then you should mention that when you attend. However, almost all types of vaccines have been reported to be associated with adverse events. COVID-19 vaccines use the spike protein of the SARS-CoV-2 virus to act as an intracellular antigen and produce an antibody response, thereby protecting against COVID-19 infection. Most pain should eventually go away, but sometimes it might carry on for longer. All data and statistics are based on publicly available data at the time of publication. There has been 963,862 people who have now received their second dose of the vaccine, as of March 4. An official website of the United States government. Keywords: Clinical trials are where a vaccine or medicine is tested on volunteers to make sure it works and is safe. Faced with a couple of days of flu-like discomfort, many people including physicians will reach for an over-the-counter medication such as ibuprofen (Advil, Motrin) or acetaminophen (Tylenol) to relieve their fever and pain. They could be covid symptoms. "I also work as a GP and we want to make sure people are taking up the vaccine and booster jabs, and by doing that we will protect the health of the nation in the best way we can.". Acute transverse myelitis after inactivated COVID-19 vaccine. RMD open. Antibodies are proteins made by the immune system to fight viruses like SARS-CoV-2. Int J Antimicrob Agents. 2006;332(2):902. INACTIVATED COVID-19 VACCINE CAN INDUCE REACTIVE POLYARTHRITIS IN OLDER PATIENTS: REPORT OF TWO CASES. Are You Fully Vaccinated Against COVID-19? 2020;6(2). It can also prevent you from having the long-lasting health problems experienced by some COVID-19 patients, or COVID-19 long haulers.. Peiris JSM. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Since reactive arthritis typically happens due to an infection, the patient was tested for Brucellosis (Using Wright, Combs Wright, and 2ME tests) and Tuberculosis (Using PPD skin test) as two of the primary organisms causing ReA. The scientists, from the Universities of Oxford and Edinburgh, compared the levels of neurological conditions seen within a month of having a first Covid jab, to those seen within a month of a positive coronavirus test. Some stiffness, pain, and swelling for several days after the vaccination is a normal reaction. Staff giving the vaccine are trained to deal with allergic reactions and treat them immediately. More often after the second dose 2005;19(4):96380, x. https://doi.org/10.1016/j.idc.2005.09.002. Vaccines play an essential role in preventing the spread. What's the least amount of exercise we can get away with? plan the things you need to do each day to help you keep on top of your pain pace yourself - if your pain is stopping you completing a task you can try again later try to relax - this can be hard, but finding something which relaxes you will reduce the stress . There has never been a stronger case to get vaccinated than the present. To our knowledge, this is the first case of monoarticular ReA in the hip after COVID-19. Here's How to Tell. -. MM, TE and RS carried out the physical examinations. So it is important to continue to follow current national guidance. For people aged 40 or over and those with other health conditions, the benefits of being vaccinated with the Oxford/AstraZeneca vaccine outweigh any risk of clotting problems. ISS):689703. "But there is overwhelming evidence of the effectiveness of the vaccine against serious illness. My niece got her second shot and had many covid symptoms . Chest pain Shortness of breath Feelings of having a fast-beating, fluttering, or pounding heart Myocarditis and pericarditis have rarely been reported. Enteric infections were also symptomatically ruled out. The most recent research on the Omicron variant suggests it lives longer on surfaces than previous coronavirus variants. Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy adults aged 60 years and older: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial. SARS-COV-2 has been shown to cause multi-organ involvement such as neurologic and gastrointestinal symptoms by triggering autoimmune reactions, leading to reactive arthritis. COVID-19 mRNA Vaccine BNT162b2 is given to adults and. Product information on COVID-19 vaccines and medicines is available on this page. Corona Virus Disease-19 Vaccine-associated Autoimmune Disorders. @Jersey Born~ Thank you so much for your reply. PubMed The COVID-19 vaccines that you have had has been shown to reduce the chance of you suffering from COVID-19 disease. Please enable it to take advantage of the complete set of features! You don't have to spend long online to stumble on posts falsely claiming Covid vaccines are causing all kinds of frightening side effects. 2022 Sep;8(2):e002026. You can also report suspected side effects of vaccines and medicines online through the Yellow Card scheme or by downloading the Yellow Card app. British Sign Language (BSL) doi: 10.12659/AJCR.927076. I haven't received the shot but I did recover from the virus; and one of my biggest symptoms was lower back pain. We use your sign-up to provide content in ways you've consented to and to improve our understanding of you. Privacy | Although a fever can occur within a day or two of vaccination, if you have any other COVID-19 symptoms or your fever lasts longer, stay at home and arrange to have a test. Pathogenesis of ankylosing spondylitis and reactive arthritis. After ultrasound and MRI, she was diagnosed with reactive arthritis inflammation in the hip's neck. If your pain in your lower back and left hip s not resolving it may be a sign of a problem. For people under 40 without other health conditions, it's preferable for you to have the Pfizer/BioNTech or Moderna vaccine instead of the Oxford/AstraZeneca vaccine. And this latest research gives a reassuring message. Clinical symptoms were resolved after being treated using a combination of indomethacin and depot methyl-prednisolone for 14 days. A diagnosis of possible COVID-19-associated ReA was established based on the lab results and the images. Serious allergic reactions to the COVID-19 vaccines are very rare. Tropical Diseases, Travel Medicine and Vaccines You cannot catch COVID-19 from the vaccine, but you may have caught it just before or after your vaccination. But these records on their own cannot tell us whether they were caused by the jab. I would recommend waiting until someone experiences side effects of fever or pain that require fever-reducing or pain-reducing medications, she said, and not to take them as a prophylaxis to prevent vaccine related symptoms.. 2). An increase in thickness is seen in the synovium and also articular effusion in the hips neck with a 7mm diameter. Check benefits and financial support you can get, Find out about the Energy Bills Support Scheme, COVID-19 vaccination: what to expect after vaccination, What to do if you are concerned about your symptoms. PubMed PubMedGoogle Scholar. QVC is not responsible for the availability, content, security, policies, or practices of the above referenced third-party linked sites nor liable for statements, claims, opinions, or representations contained therein. Additionally, MRI revealed a fluid rim around the pelvic area, suggesting inflammation in the right hip and sacroiliitis (Fig. Saturday, 4th March 2023See today's front and back pages, download the newspaper, order back issues and use the historic Daily Express newspaper archive. Clinical trials are where a vaccine or medicine is tested on volunteers to make sure it works and is safe. New COVID-19 boosters could be authorized by the FDA before full data from human trials are in because of past data on similar vaccines. For the COVID-19 vaccines Pfizer and Moderna, you have six hours from the time the vial is punctured. Both Pfizer and Moderna have acknowledged that their vaccines could induce side effects that are similar to symptoms associated with mild Covid-19, such as muscle pain, chills and headache. Other known microorganisms responsible for reactive arthritis were ruled out before attributing it to the earlier COVID-19 infection. I received my second vaccine on February 4th, and have been experiencing pain in lower back and left hip. Back to If you feel unwell or very tired you should rest and avoid operating machinery or driving. The BBC is not responsible for the content of external sites. Digestive symptoms, like stomach pain, might be among the earliest symptoms of COVID-19 that you experience. However, an itchy throat is more commonly associated with allergies. Doctors say the landmark UK study provides further. Reactive arthritis after SARS-CoV-2 infection. Some patients may experience side effects after vaccination, but these are typically mild and go away in a few days. However, none of these two patients had any symptoms in their hip since their ReA had mainly affected smaller joints, particularly in the hands. With the. He had his second dose of the coronavirus vaccine last week and took ibuprofen afterwards for a low-grade fever and some aches. 2 from Pfizer or Moderna, many people feel an all-over malaise, with chills, potential for fever, and body aches. Jiang F, Deng L, Zhang L, Cai Y, Cheung CW, Xia Z. SARS-COV-2 infection was previously thought to only display respiratory symptoms as part of the coronaviridae family [3, 4]; The rapid spread of this virus, however, revealed various sequelae and symptoms, with the autoimmune system having a prominent role in most of these reactions [5, 6]. Reactive arthritis in the right hip following COVID-19 infection: a case report, Tropical Diseases, Travel Medicine and Vaccines, https://doi.org/10.1186/s40794-021-00142-6, https://doi.org/10.1016/j.jaad.2008.02.047, https://doi.org/10.1007/s11606-020-05762-w, https://doi.org/10.1016/j.ijantimicag.2020.105954, https://doi.org/10.1016/j.jclinepi.2013.08.003, https://doi.org/10.1097/01.bor.0000163447.44037.c4, https://doi.org/10.1097/01.JAA.0000558320.47868.2f, https://doi.org/10.1097/00000441-200608000-00008, https://doi.org/10.1016/j.idc.2005.09.002, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/. Accessibility CoronaVac vaccine; adverse event; reactive arthritis. But additional studies would be needed to know for certain. In: Clinical Virology. She was started on interferon 1, dexamethasone, ceftriaxone, enoxaparin, and nortriptyline and was discharged after 5days with oxygen levels of 92%. FOIA She showed dramatic improvement starting 5days after her visit and reached remission after 14days. There is currently no direct evidence to suggest that a corticosteroid injection before or after the administration of an mRNA COVID-19 vaccine decreases the efficacy of the vaccine.However, based on the known timeline of hypothalamic-pituitary-adrenal (HPA) axis suppression following epidural and intraarticular corticosteroid injections, and But if these drugs reduce the side effects of the vaccine, is there a chance that theyll also depress the immune systems beneficial response to vaccination? Kristen has had ankylosing spondylitis (AS), a type of inflammatory arthritis that causes debilitating back and hip pain, as well as other symptoms, for more than 20 years. 8600 Rockville Pike Two other reactive arthritis cases following infection with SARS-COV-2 were reported, one of a 57years old man in Japan and the other of a 73years old man in Turkey [14, 15]. I had neck and lower back pain as well as a headache. Pfizer released the following statement: "We take adverse events that are potentially associated with our COVID-19 vaccine, BNT162b2, very seriously. Do. Accordingly, we could not entirely rule out gastrointestinal infections, test the patients for STIs, or obtain a patients synovial fluid sample. J Orthop Case Rep. 2021 Mar;11(3):79-84. doi: 10.13107/jocr.2021.v11.i03.2098. Pfizer Says Bivalent COVID-19 Booster Significantly Increases Antibodies to Fight Omicron. While this complication is more likely to occur following sexually transmitted or gastrointestinal infections, other infections such as COVID-19 can lead to reactive arthritis as well. 1996;39(7):11727. Unauthorized use of these marks is strictly prohibited. Some earlier research in the laboratory suggests that fever-reducing pain medications may blunt the antibody response to vaccination, but its not clear what this means in the real world. Tell healthcare staff before you're vaccinated if you've ever had a serious allergic reaction (including anaphylaxis). 2019;32(7):258. Lung cancer symptoms: The simple finger test to find out if youre at risk of the disease, Type 2 diabetes: 'Foot drop' is warning sign, Vitamin B12 deficiency: Irreversible signs, Covid vaccine side effects: Why some people have a severe reaction, Covid new strain: Dr warned immunity from vaccine 'will be blunted', Covid vaccine: The six side effects you might have after jab. They may ask what you're allergic to, to make sure you can have the vaccine. COVID-19 can affect and even shrink certain parts of your brain. Its a nagging, throbbing type pain. Reactive arthritis in the right hip following COVID-19 infection: a case report Authors Kamyar Shokraee 1 , Soroush Moradi 2 , Tahereh Eftekhari 3 , Rasoul Shajari 3 , Maryam Masoumi 4 Affiliations 1 Tehran University of Medical Sciences, Tehran, Iran. 2022 Sep;8(2):e002519. https://doi.org/10.1097/01.JAA.0000558320.47868.2f. DON'T MISSHigh blood pressure: 75p fruit to reduce risk [TIPS]Diabetes type 2: Four sensations in the feet [INSIGHT]The habit that increases longevity by 50% [ADVICE]. https://doi.org/10.1097/01.bor.0000163447.44037.c4. "Serious adverse events that are unrelated to the vaccine are unfortunately likely to occur at a similar rate as they would in the general population.". 2022 Oct 10;9:933914. doi: 10.3389/fmed.2022.933914. COVID-19 Vaccine: Key FDA Panel Supports Updated Annual Shots. Learn how this happens and if you can prevent it. Bookshelf Only a few cases of arthritis caused by COVID-19 have been reported until now. 2020;55(5):105954. https://doi.org/10.1016/j.ijantimicag.2020.105954.

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hip pain after covid vaccine pfizer

hip pain after covid vaccine pfizer